Publications
- Khabibullina NF, Tereshchenkov AG, Komarova ES, Syroegin EA, Shiriaev DI, Paleskava A, Kartsev VG, Bogdanov AA, Konevega AL, Dontsova OA, Sergiev PV, Osterman IA*, and Polikanov YS*. (2019) Structure of dirithromycin bound to the bacterial ribosome suggests new ways for rational improvement of macrolides. Antimicrobial Agents and Chemotherapy, in press.
- Svetlov MS, Plessa E, Chen CW, Bougas A, Krokidis MG, Dinos GP*, and Polikanov YS*. (2019) High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition. RNA Journal, doi: 10.1261/rna.069260.118.
- Matsushita T, Sati G, Kondasinghe N, Pirrone M, Kato T, Waduge P, Kumar H, Sanchon A, Dobosz-Bartoszek M, Shcherbakov D, Juhas M, Hobbie SN, Schrepfer T, Chow CS, Polikanov YS, Schacht J, Vasella A, Böttger EC*, and Crich D*. (2019) Design, multigram synthesis, and in vitro and in vivo evaluation of propylamycin: a semisynthetic 4,5-deoxystreptamine class aminoglycoside for the treatment of drug-resistant Enterobacteriaceae and other Gram-negative pathogens. Journal of American Chemical Society, doi: 10.1021/jacs.9b01693.
- Juhas M, Widlake E, Teo J, Huseby DL, Tyrrell JM, Polikanov YS, Ercan O, Petersson A, Cao S, Aboklaish AF, Rominski A, Crich D, Böttger EC, Walsh TR, Hughes D, and Hobbie SN*. (2019) In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii. Journal of Antimicrobial Chemotherapy 74(4): 944-952.
- Melnikov SV, Khabibullina NF, Mairhofer E, Vargas-Rodriguez O, Reynolds NM, Micura R*, Söll D*, and Polikanov YS*. (2018) Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site. Nucleic Acids Research47(4): 2089-2100.
- Pantel L, Florin T, Dobosz-Bartoszek M, Racine E, Sarciaux M, Serri M, Houard J, Campagne JM, Marcia de Figueiredo R, Midrier C, Gaudriault S, Givaudan A, Lanois A, Forst S, Aumelas A, Cotteaux-Lautard C, Bolla JM, Vingsbo Lundberg C, Huseby DL, Hughes D, Villain-Guillot P, Mankin AS*, Polikanov YS*, and Gualtieri G*. (2018) Odilorhabdins, antibacterial agents that cause miscoding by binding at a new ribosomal site. Molecular Cell 70(1): 83-94.
- Lin J, Zhou D, Steitz TA*, Polikanov YS*, and Gagnon MG*. (2018) Ribosome-targeting antibiotics: Modes of action, mechanisms of resistance, and implications for drug design. Annual Review of Biochemistry 87: 451-478.
- Polikanov YS*, Aleksashin NA, Beckert B, and Wilson DN*. (2018) The mechanisms of action of ribosome-targeting peptide antibiotics. Frontiers in Molecular Biosciences 5: 48.
- Tereshchenkov AG, Dobosz-Bartoszek M, Osterman IA, Marks J, Sergeeva VA, Kasatsky P, Komarova ES, Stavrianidi AA, Rodin IA, Konevega AL, Sergiev PV, Sumbatyan NV, Mankin AS, Bogdanov AA*, and Polikanov YS*. (2018) Binding and action of amino acid analogs of chloramphenicol upon the bacterial ribosome. Journal of Molecular Biology 430(6): 842-852.
- Sergiev PV, Aleksashin NA, Chugunova AA, Polikanov YS*, and Dontsova OA*. (2018) Structural and evolutionary insights into ribosomal RNA methylation. Nature Chemical Biology 14(3): 226-235.
- Metelev M, Osterman IA, Ghilarov D, Khabibullina NF, Yakimov A, Shabalin K, Utkina I, Travin DY, Komarova ES, Serebryakova M, Artamonova T, Khodorkovskii M, Konevega AL, Sergiev PV, Severinov K*, and Polikanov YS*. (2017) Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel. Nature Chemical Biology 13(10): 1129-1136.
- Almutairi MM, Svetlov MS, Hansen DA, Khabibullina NF, Klepacki D, Kang HY, Sherman DH, Vázquez-Laslop N, Polikanov YS*, and Mankin AS*. (2017) Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins. Nucleic Acids Research 45(16): 9573-9582.
- Osterman IA, Khabibullina NF, Komarova ES, Kasatsky P, Kartsev VG, Bogdanov AA, Dontsova OA, Konevega AL*, Sergiev PV*, and Polikanov YS*. (2017) Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.Nucleic Acids Research 45(12): 7507-7514.
- Karabadzhak AG, Petti LM, Barrera FN, Edwards APB, Moya-Rodríguez A, Polikanov YS, Freites JA, Tobias DJ, Engelman DM*, and DiMaio D*. (2017) Two transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF β receptor in an active dimeric conformation. Proceedings of the National Academy of Sciences USA 114(35): E7262-E7271.
- Arenz S, Juette MF, Graf M, Nguyen F, Huter P, Polikanov YS*, Blanchard SC*, and Wilson DN*. (2016) Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. Proceedings of the National Academy of Sciences USA 113(27): 7527-7532.
- Melnikov SV, Söll D, Steitz TA*, Polikanov YS*. (2016) Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome. Nucleic Acids Research 44(10): 4978-4987.